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Dev.SN ♥ developers

posted by The Mighty Buzzard on Friday December 02 2016, @09:24PM   Printer-friendly
from the fill-er-up dept.
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  • (Score: 0) by Anonymous Coward on Saturday December 17 2016, @02:46PM

    by Anonymous Coward on Saturday December 17 2016, @02:46PM (#29653)

    Figure 3

    Establishment of In Vivo Induction Protocol in 4F Mice

    (A) Body weight of 4F mice upon continuous administration of doxycycline (−Dox n = 11; +Dox n = 26).

    Figure 4

    Extension of Lifespan and Prevention of Age-Associated Phenotypes by In Vivo Induction of Oct4, Sox2, Klf4, and c-Myc

    (A) Body weight of LAKI and LAKI 4F mice upon cyclic doxycycline administration. LAKI (−Dox n = 20; +Dox n = 13) and LAKI 4F (−Dox n = 18; +Dox n = 15).

    (G) ECG analysis in LAKI 4F mice upon cyclic doxycycline administration (−Dox n = 4; +Dox n = 4). Heart rate represented as beats per minute (bpm). ∗p

    Figure 7

    Improved Resistance to Metabolic Disease and Skeletal Muscle Injury in Aged WT Animals by In Vivo Reprogramming

    (B) Glucose tolerance test (GTT) in 12-month-old WT 4F mice following beta cell ablation by low dose STZ (−Dox n = 6; +Dox n = 6). ∗∗p

    Figure S3

    Effect of Long-Term In Vivo Cyclic Induction of Oct4, Sox2, Klf4, and c-Myc in Mice Carrying One and Two Copies of OSKM and rtTA Cassette, Related to Figure 3

    (A) Body weight of wild-type (WT) and 4F mice carrying single copy of OSKM and rtTA cassette upon cyclic administration of doxycycline. WT (n = 5) and 4F (n = 3).

    Figure S7

    Analysis of Pancreatic Function and Skeletal Muscle Regeneration in Wild-Type Mice, Related to Figure 7

    (A) Glucose tolerance test (GTT) in 2-month and 12-month old WT mice following beta cell ablation by low dose (50 mg/kg) STZ (2-month WT n = 3; 12-month WT n = 3).

    (D) GTT in 12-month old WT mice following doxycycline and beta cell ablation by low dose (50 mg/kg) STZ (-Dox n = 5; +Dox n = 5).

    (I) Quantification of percentage of central nucleated fibers in muscle sections of 12-month old WT mice following doxycycline treatment and muscle injury by CTX injection (-Dox n = 3; +Dox n = 3).

    They killed these mice to death! 222