The bacterium Pseudomonas aeruginosa is one of the main causes of infections and sepsis in people suffering from severe burns because it is difficult, if not impossible, to fight. Researchers at the University of Geneva (UNIGE), Switzerland, have succeeded in revealing the dynamics of the pathogen's physiology and metabolism during its growth in exudates, the biological fluids that seep out of burn wounds.
...this study allows to follow step-by-step the strategies developed by Pseudomonas aeruginosa to proliferate and, thus, to guide the development of innovative treatments to counter them.
Manuel R. Gonzalez says:
"Since the availability of iron is a limiting factor for bacterial growth, a Trojan horse type strategy should be considered, which is under development."
Manuel R. Gonzalez, Verena Ducret, Sara Leoni, Betty Fleuchot, Paris Jafari, Wassim Raffoul, Lee A. Applegate, Yok-Ai Que, Karl Perron. Transcriptome Analysis of Pseudomonas aeruginosa Cultured in Human Burn Wound Exudates. Frontiers in Cellular and Infection Microbiology, 2018; 8 DOI: 10.3389/fcimb.2018.00039
A Bacterium That Attacks Burn Victims Will Soon be Unarmed
from the we'll-toast-to-that dept.
Arthur T Knackerbracket has found the following story:
Manuel R. Gonzalez says:
Manuel R. Gonzalez, Verena Ducret, Sara Leoni, Betty Fleuchot, Paris Jafari, Wassim Raffoul, Lee A. Applegate, Yok-Ai Que, Karl Perron. Transcriptome Analysis of Pseudomonas aeruginosa Cultured in Human Burn Wound Exudates. Frontiers in Cellular and Infection Microbiology, 2018; 8 DOI: 10.3389/fcimb.2018.00039
Original Submission